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IgG cooperativity – Is there allostery? Implications for antibody functions and therapeutic antibody development
A central dogma in immunology is that an antibody's in vivo functionality is mediated by 2 independent events: antigen binding by the variable (V) region, followed by effector activation by the constant (C) region. However, this view has recently been challenged by reports suggesting allostery...
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| Publicado no: | MAbs |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5680800/ https://ncbi.nlm.nih.gov/pubmed/28812955 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2017.1367074 |
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