Calcium/calmodulin-dependent kinase kinase 2 regulates hematopoietic stem and progenitor cell regeneration

Hematopoietic stem and progenitor cells (HSPCs) are predominantly quiescent in adults, but proliferate in response to bone marrow (BM) injury. Here, we show that deletion of Ca(2+)/calmodulin (CaM)-dependent protein kinase kinase 2 (CaMKK2) promotes HSPC regeneration and hematopoietic recovery follo...

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Publicat a:Cell Death Dis
Autors principals: Racioppi, Luigi, Lento, William, Huang, Wei, Arvai, Stephanie, Doan, Phuong L, Harris, Jeffrey R, Marcon, Fernando, Nakaya, Helder I, Liu, Yaping, Chao, Nelson
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5680595/
https://ncbi.nlm.nih.gov/pubmed/28981105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.474
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