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BCR–ABL1-induced downregulation of WASP in chronic myeloid leukemia involves epigenetic modification and contributes to malignancy

Chronic myeloid leukemia (CML) is a myeloproliferative disease caused by the BCR–ABL1 tyrosine kinase (TK). The development of TK inhibitors (TKIs) revolutionized the treatment of CML patients. However, TKIs are not effective to those at advanced phases when amplified BCR–ABL1 levels and increased g...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Pereira, Welbert O, De Carvalho, Daniel D, Zenteno, Maria Emilia, Ribeiro, Beatriz F, Jacysyn, Jacqueline F, Sardinha, Luiz R, Zanichelli, Maria A, Hamerschlak, Nelson, Jones, Gareth E, Pagnano, Katia B, Castro, Fabiola A, Calle, Yolanda, Amarante-Mendes, Gustavo P
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5680580/
https://ncbi.nlm.nih.gov/pubmed/29022901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.458
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