A water-soluble nucleolin aptamer-paclitaxel conjugate for tumor-specific targeting in ovarian cancer

Paclitaxel (PTX) is among the most commonly used first-line drugs for cancer chemotherapy. However, its poor water solubility and indiscriminate distribution in normal tissues remain clinical challenges. Here we design and synthesize a highly water-soluble nucleolin aptamer-paclitaxel conjugate (Nuc...

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Pubblicato in:Nat Commun
Autori principali: Li, Fangfei, Lu, Jun, Liu, Jin, Liang, Chao, Wang, Maolin, Wang, Luyao, Li, Defang, Yao, Houzong, Zhang, Qiulong, Wen, Jia, Zhang, Zong-Kang, Li, Jie, Lv, Quanxia, He, Xiaojuan, Guo, Baosheng, Guan, Daogang, Yu, Yuanyuan, Dang, Lei, Wu, Xiaohao, Li, Yongshu, Chen, Guofen, Jiang, Feng, Sun, Shiguo, Zhang, Bao-Ting, Lu, Aiping, Zhang, Ge
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5680242/
https://ncbi.nlm.nih.gov/pubmed/29123088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01565-6
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