Tumor suppressor Pdcd4attenuates Sin1 translation to inhibit invasion in colon carcinoma

Programmed cell death 4 (Pdcd4), a tumor invasion suppressor, is frequently down-regulated in colorectal cancer and other cancers. In this study, we find that loss of Pdcd4 increases the activity of mammalian target of rapamycin complex 2 (mTORC2) and thereby upregulates Snail expression. Examining...

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Gepubliceerd in:Oncogene
Hoofdauteurs: Wang, Qing, Zhu, Jiang, Wang, Ya-Wen, Dai, Yong, Wang, Yanlei, Wang, Chi, Liu, Jinpeng, Baker, Alyson, Colburn, Nancy H., Yang, Hsin-Sheng
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5680133/
https://ncbi.nlm.nih.gov/pubmed/28692058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2017.228
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