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Structural Basis for Inhibition of Translation by the Tumor Suppressor Pdcd4

The tumor suppressor function of Programmed Cell Death 4 (Pdcd4) is achieved through interactions between Pdcd4 and components of the translation initiation complex, namely, the RNA helicase eIF4A and the scaffolding protein eIF4G. These interactions are mediated through two MA3 domains on the Pdcd4...

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Autors principals: LaRonde-LeBlanc, Nicole, Santhanam, Arti N., Baker, Alyson R., Wlodawer, Alexander, Colburn, Nancy H.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1800662/
https://ncbi.nlm.nih.gov/pubmed/17060447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00867-06
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