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Structural basis for translational inhibition by the tumour suppressor Pdcd4

Pdcd4 is a tumour suppressor protein. It inhibits translation through interaction with translation initiator eIF4A, resulting in the suppression of neoplastic transformation and tumour invasion. Here, we present the crystal structures of an N-terminal-truncated Pdcd4 in free form and in complex with...

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Bibliografski detalji
Glavni autori: Loh, Portia G, Yang, Hsin-Sheng, Walsh, Martin A, Wang, Qing, Wang, Xiaoxing, Cheng, Zhihong, Liu, Dingxiang, Song, Haiwei
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2637334/
https://ncbi.nlm.nih.gov/pubmed/19153607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.278
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