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Structural basis for translational inhibition by the tumour suppressor Pdcd4
Pdcd4 is a tumour suppressor protein. It inhibits translation through interaction with translation initiator eIF4A, resulting in the suppression of neoplastic transformation and tumour invasion. Here, we present the crystal structures of an N-terminal-truncated Pdcd4 in free form and in complex with...
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| Auteurs principaux: | , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2637334/ https://ncbi.nlm.nih.gov/pubmed/19153607 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.278 |
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