Tumorigenesis Suppressor Pdcd4 Down-Regulates Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1 Expression To Suppress Colon Carcinoma Cell Invasion

Programmed cell death 4 (Pdcd4) suppresses neoplastic transformation by inhibiting the activation of c-Jun and consequently AP-1-dependent transcription. We report that Pdcd4 blocks c-Jun activation by inhibiting the expression of mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1)/hema...

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Bibliographische Detailangaben
Hauptverfasser: Yang, Hsin-Sheng, Matthews, Connie P., Clair, Timothy, Wang, Qing, Baker, Alyson R., Li, Chou-Chi H., Tan, Tse-Hua, Colburn, Nancy H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2006
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1367180/
https://ncbi.nlm.nih.gov/pubmed/16449643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.4.1297-1306.2006
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