Targeting Glioma Stem Cells through Combined BMI1 and EZH2 Inhibition

Glioblastomas are lethal cancers defined by angiogenesis and pseudopalisading necrosis. Here, we demonstrate that these histological features are associated with distinct transcriptional programs, with vascular regions showing a proneural profile and hypoxic regions a mesenchymal pattern. As these r...

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izdano v:Nat Med
Main Authors: Jin, Xun, Kim, Leo J. Y., Wu, Qiulian, Wallace, Lisa C., Prager, Briana C., Sanvoranart, Tanwarat, Gimple, Ryan C., Wang, Xiuxing, Mack, Stephen C., Miller, Tyler E., Huang, Ping, Valentim, Claudia L., Zhou, Qi-gang, Barnholtz-Sloan, Jill S., Bao, Shideng, Sloan, Andrew E., Rich, Jeremy N.
Format: Artigo
Jezik:Inglês
Izdano: 2017
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5679732/
https://ncbi.nlm.nih.gov/pubmed/29035367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4415
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