EXTH-37. TARGETING GLIOMA STEM CELLS THROUGH COMBINED BMI1 AND EZH2 INHIBITION

Glioblastomas are lethal cancers defined by angiogenesis and pseudopalisading necrosis. Here, we demonstrate that these features are associated with distinct transcriptional programs, with vascular regions showing a proneural profile and hypoxic regions a mesenchymal pattern. As these regions harbor...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Jin, Xun, Kim, Leo, Wu, Qiulian, Wallace, Lisa C, Prager, Briana, Sanvoranart, Tanwarat, Gimple, Ryan, Mack, Stephen, Miller, Tyler E, Huang, Ping, Barnholtz-Sloan, Jill, Bao, Shideng, Sloan, Andrew, Rich, Jeremy
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2017
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Abstracts
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692695/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.329
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