EXTH-37. TARGETING GLIOMA STEM CELLS THROUGH COMBINED BMI1 AND EZH2 INHIBITION

Glioblastomas are lethal cancers defined by angiogenesis and pseudopalisading necrosis. Here, we demonstrate that these features are associated with distinct transcriptional programs, with vascular regions showing a proneural profile and hypoxic regions a mesenchymal pattern. As these regions harbor...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Jin, Xun, Kim, Leo, Wu, Qiulian, Wallace, Lisa C, Prager, Briana, Sanvoranart, Tanwarat, Gimple, Ryan, Mack, Stephen, Miller, Tyler E, Huang, Ping, Barnholtz-Sloan, Jill, Bao, Shideng, Sloan, Andrew, Rich, Jeremy
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692695/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.329
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