EXTH-37. TARGETING GLIOMA STEM CELLS THROUGH COMBINED BMI1 AND EZH2 INHIBITION

Glioblastomas are lethal cancers defined by angiogenesis and pseudopalisading necrosis. Here, we demonstrate that these features are associated with distinct transcriptional programs, with vascular regions showing a proneural profile and hypoxic regions a mesenchymal pattern. As these regions harbor...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Neuro Oncol
Päätekijät: Jin, Xun, Kim, Leo, Wu, Qiulian, Wallace, Lisa C, Prager, Briana, Sanvoranart, Tanwarat, Gimple, Ryan, Mack, Stephen, Miller, Tyler E, Huang, Ping, Barnholtz-Sloan, Jill, Bao, Shideng, Sloan, Andrew, Rich, Jeremy
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2017
Aiheet:
Abstracts
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692695/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.329
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