Targeting Glioma Stem Cells through Combined BMI1 and EZH2 Inhibition

Glioblastomas are lethal cancers defined by angiogenesis and pseudopalisading necrosis. Here, we demonstrate that these histological features are associated with distinct transcriptional programs, with vascular regions showing a proneural profile and hypoxic regions a mesenchymal pattern. As these r...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Med
Main Authors: Jin, Xun, Kim, Leo J. Y., Wu, Qiulian, Wallace, Lisa C., Prager, Briana C., Sanvoranart, Tanwarat, Gimple, Ryan C., Wang, Xiuxing, Mack, Stephen C., Miller, Tyler E., Huang, Ping, Valentim, Claudia L., Zhou, Qi-gang, Barnholtz-Sloan, Jill S., Bao, Shideng, Sloan, Andrew E., Rich, Jeremy N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5679732/
https://ncbi.nlm.nih.gov/pubmed/29035367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4415
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados