ED SUMM: B cell VH region repertoire sequencing of 8 anatomical sites in 6 human donors reveals distinct networks of clone distribution: An atlas of B cell clonal distribution in the human body

B cell responses result in clonal expansion, and can occur in a variety of tissues. To define how B cell clones are distributed in the body, we sequenced 933,427 B cell clonal lineages and mapped them to 8 different anatomic compartments in 6 human organ donors. We show that large B cell clones part...

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Publié dans:Nat Biotechnol
Auteurs principaux: Meng, Wenzhao, Zhang, Bochao, Schwartz, Gregory W., Rosenfeld, Aaron M., Ren, Daqiu, Thome, Joseph J.C., Carpenter, Dustin J., Matsuoka, Nobuhide, Lerner, Harvey, Friedman, Amy L., Granot, Tomer, Farber, Donna L., Shlomchik, Mark J., Hershberg, Uri, Luning Prak, Eline T.
Format: Artigo
Langue:Inglês
Publié: 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5679700/
https://ncbi.nlm.nih.gov/pubmed/28829438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3942
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