Computational Evaluation of B-Cell Clone Sizes in Bulk Populations

B cell clones expand and contract during adaptive immune responses and can persist or grow uncontrollably in lymphoproliferative disorders. One way to monitor and track B cell clones is to perform large-scale sampling of bulk cell populations, amplifying, and sequencing antibody gene rearrangements...

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Gepubliceerd in:Front Immunol
Hoofdauteurs: Rosenfeld, Aaron M., Meng, Wenzhao, Chen, Dora Y., Zhang, Bochao, Granot, Tomer, Farber, Donna L., Hershberg, Uri, Luning Prak, Eline T.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2018
Onderwerpen:
Immunology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6034424/
https://ncbi.nlm.nih.gov/pubmed/30008715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01472
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