Trials and Tribulations with VH Replacement

VH replacement (VHR) is a type of antibody gene rearrangement in which an upstream heavy chain variable gene segment (VH) invades a pre-existing rearrangement (VDJ). In this Hypothesis and Theory article, we begin by reviewing the mechanism of VHR, its developmental timing and its potential biologic...

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Detalhes bibliográficos
Main Authors: Meng, Wenzhao, Jayaraman, Sahana, Zhang, Bochao, Schwartz, Gregory W., Daber, Robert D., Hershberg, Uri, Garfall, Alfred L., Carlson, Christopher S., Luning Prak, Eline T.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3906580/
https://ncbi.nlm.nih.gov/pubmed/24523721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2014.00010
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