Ribavirin suppresses hepatic lipogenesis through inosine monophosphate dehydrogenase inhibition: Involvement of adenosine monophosphate‐activated protein kinase‐related kinases and retinoid X receptor α

Ribavirin (RBV) has been widely used as an antiviral reagent, specifically for patients with chronic hepatitis C. We previously demonstrated that adenosine kinase, which monophosphorylates RBV into the metabolically active form, is a key determinant for RBV sensitivity against hepatitis C virus RNA...

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Veröffentlicht in:Hepatol Commun
Hauptverfasser: Satoh, Shinya, Mori, Kyoko, Onomura, Daichi, Ueda, Youki, Dansako, Hiromichi, Honda, Masao, Kaneko, Shuichi, Ikeda, Masanori, Kato, Nobuyuki
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2017
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5678905/
https://ncbi.nlm.nih.gov/pubmed/29404478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep4.1065
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