Ethanol‐induced steatosis involves impairment of lipophagy, associated with reduced Dynamin2 activity

Lipid droplets (LDs), the organelles central to alcoholic steatosis, are broken down by lipophagy, a specialized form of autophagy. Here, we hypothesize that ethanol administration retards lipophagy by down‐regulating dynamin 2 (Dyn2), a protein that facilitates lysosome re‐formation, contributing t...

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Bibliografiske detaljer
Udgivet i:Hepatol Commun
Main Authors: Rasineni, Karuna, Donohue, Terrence M., Thomes, Paul G., Yang, Li, Tuma, Dean J., McNiven, Mark A., Casey, Carol A.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2017
Fag:
Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5678901/
https://ncbi.nlm.nih.gov/pubmed/29152606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep4.1063
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