The Enzymatic and Structural Basis for Inhibition of Echinococcus granulosus Thioredoxin Glutathione Reductase by Gold(I)

Aims: New drugs are needed to treat flatworm infections that cause severe human diseases such as schistosomiasis. The unique flatworm enzyme thioredoxin glutathione reductase (TGR), structurally different from the human enzyme, is a key drug target. Structural studies of the flatworm Echinococcus gr...

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Detalles Bibliográficos
Publicado en:Antioxid Redox Signal
Autores principales: Salinas, Gustavo, Gao, Wei, Wang, Yang, Bonilla, Mariana, Yu, Long, Novikov, Andrey, Virginio, Veridiana G., Ferreira, Henrique B., Vieites, Marisol, Gladyshev, Vadim N., Gambino, Dinorah, Dai, Shaodong
Formato: Artigo
Lenguaje:Inglês
Publicado: Mary Ann Liebert, Inc. 2017
Materias:
Original Research Communications
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5678357/
https://ncbi.nlm.nih.gov/pubmed/28463568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2016.6816
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