Platyhelminth Mitochondrial and Cytosolic Redox Homeostasis Is Controlled by a Single Thioredoxin Glutathione Reductase and Dependent on Selenium and Glutathione

Platyhelminth parasites are a major health problem in developing countries. In contrast to their mammalian hosts, platyhelminth thiol-disulfide redox homeostasis relies on linked thioredoxin-glutathione systems, which are fully dependent on thioredoxin-glutathione reductase (TGR), a promising drug t...

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Autors principals: Bonilla, Mariana, Denicola, Ana, Novoselov, Sergey V., Turanov, Anton A., Protasio, Anna, Izmendi, Darwin, Gladyshev, Vadim N., Salinas, Gustavo
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2008
Matèries:
Enzyme Catalysis and Regulation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2440607/
https://ncbi.nlm.nih.gov/pubmed/18408002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M710609200
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