The Enzymatic and Structural Basis for Inhibition of Echinococcus granulosus Thioredoxin Glutathione Reductase by Gold(I)

Aims: New drugs are needed to treat flatworm infections that cause severe human diseases such as schistosomiasis. The unique flatworm enzyme thioredoxin glutathione reductase (TGR), structurally different from the human enzyme, is a key drug target. Structural studies of the flatworm Echinococcus gr...

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Detalhes bibliográficos
Publicado no:Antioxid Redox Signal
Main Authors: Salinas, Gustavo, Gao, Wei, Wang, Yang, Bonilla, Mariana, Yu, Long, Novikov, Andrey, Virginio, Veridiana G., Ferreira, Henrique B., Vieites, Marisol, Gladyshev, Vadim N., Gambino, Dinorah, Dai, Shaodong
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2017
Assuntos:
Original Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5678357/
https://ncbi.nlm.nih.gov/pubmed/28463568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2016.6816
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