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Sialidase inhibitors attenuate pulmonary fibrosis in a mouse model
Fibrosis involves increasing amounts of scar tissue appearing in a tissue, but what drives this is unclear. In fibrotic lesions in human and mouse lungs, we found extensive desialylation of glycoconjugates, and upregulation of sialidases. The fibrosis-associated cytokine TGF-β1 upregulates sialidase...
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| Udgivet i: | Sci Rep |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5678159/ https://ncbi.nlm.nih.gov/pubmed/29118338 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-15198-8 |
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