Valproic Acid Sensitizes Hepatocellular Carcinoma Cells to Proton Therapy by Suppressing NRF2 Activation

Although efficacy of combined histone deacetylase (HDAC) inhibitors and conventional photon radiotherapy is being tested in clinical trials, their combined effect with proton beam radiotherapy has yet to be determined. Here, we compared combined effect of valproic acid (VPA), a class I and II HDAC i...

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Publicat a:Sci Rep
Autors principals: Yu, Jeong Il, Choi, Changhoon, Shin, Sung-Won, Son, Arang, Lee, Ga-Haeng, Kim, Shin-Yeong, Park, Hee Chul
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5678087/
https://ncbi.nlm.nih.gov/pubmed/29118323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-15165-3
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