Valproic Acid Sensitizes Hepatocellular Carcinoma Cells to Proton Therapy by Suppressing NRF2 Activation

Although efficacy of combined histone deacetylase (HDAC) inhibitors and conventional photon radiotherapy is being tested in clinical trials, their combined effect with proton beam radiotherapy has yet to be determined. Here, we compared combined effect of valproic acid (VPA), a class I and II HDAC i...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Yu, Jeong Il, Choi, Changhoon, Shin, Sung-Won, Son, Arang, Lee, Ga-Haeng, Kim, Shin-Yeong, Park, Hee Chul
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5678087/
https://ncbi.nlm.nih.gov/pubmed/29118323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-15165-3
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