Workflow optimization of whole genome amplification and targeted panel sequencing for CTC mutation detection

Genomic characterization of circulating tumor cells (CTCs) may prove useful as a surrogate for conventional tissue biopsies. This is particularly important as studies have shown different mutational profiles between CTCs and ctDNA in some tumor subtypes. However, isolating rare CTCs from whole blood...

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Udgivet i:NPJ Genom Med
Main Authors: Liu, Haiyan E., Triboulet, Melanie, Zia, Amin, Vuppalapaty, Meghah, Kidess-Sigal, Evelyn, Coller, John, Natu, Vanita S., Shokoohi, Vida, Che, James, Renier, Corinne, Chan, Natalie H., Hanft, Violet R., Jeffrey, Stefanie S., Sollier-Christen, Elodie
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5677973/
https://ncbi.nlm.nih.gov/pubmed/29263843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41525-017-0034-3
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