Workflow optimization of whole genome amplification and targeted panel sequencing for CTC mutation detection

Genomic characterization of circulating tumor cells (CTCs) may prove useful as a surrogate for conventional tissue biopsies. This is particularly important as studies have shown different mutational profiles between CTCs and ctDNA in some tumor subtypes. However, isolating rare CTCs from whole blood...

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Gepubliceerd in:NPJ Genom Med
Hoofdauteurs: Liu, Haiyan E., Triboulet, Melanie, Zia, Amin, Vuppalapaty, Meghah, Kidess-Sigal, Evelyn, Coller, John, Natu, Vanita S., Shokoohi, Vida, Che, James, Renier, Corinne, Chan, Natalie H., Hanft, Violet R., Jeffrey, Stefanie S., Sollier-Christen, Elodie
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5677973/
https://ncbi.nlm.nih.gov/pubmed/29263843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41525-017-0034-3
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