Targeted Metabolomics Reveals Abnormal Hepatic Energy Metabolism by Depletion of β-Carotene Oxygenase 2 in Mice

β-carotene oxygenase 2 (BCO2) is a carotenoid cleavage enzyme located in the inner mitochondrial membrane. Ablation of BCO2 impairs mitochondrial function leading to oxidative stress. Herein, we performed a targeted metabolomics study using ultrahigh performance liquid chromatography-tandem mass spe...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Wu, Lei, Guo, Xin, Lyu, Yi, Clarke, Stephen L., Lucas, Edralin A., Smith, Brenda J., Hildebrand, Deana, Wang, Weiqun, Medeiros, Denis M., Shen, Xinchun, Lin, Dingbo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5677115/
https://ncbi.nlm.nih.gov/pubmed/29116185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-15222-x
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