Identification of a tumor-promoter cholesterol metabolite in human breast cancers acting through the glucocorticoid receptor

Breast cancer (BC) remains the primary cause of death from cancer among women worldwide. Cholesterol-5,6-epoxide (5,6-EC) metabolism is deregulated in BC but the molecular origin of this is unknown. Here, we have identified an oncometabolism downstream of 5,6-EC that promotes BC progression independ...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Voisin, Maud, de Medina, Philippe, Mallinger, Arnaud, Dalenc, Florence, Huc-Claustre, Emilie, Leignadier, Julie, Serhan, Nizar, Soules, Régis, Ségala, Grégory, Mougel, Aurélie, Noguer, Emmanuel, Mhamdi, Loubna, Bacquié, Elodie, Iuliano, Luigi, Zerbinati, Chiara, Lacroix-Triki, Magali, Chaltiel, Léonor, Filleron, Thomas, Cavaillès, Vincent, Al Saati, Talal, Rochaix, Philippe, Duprez-Paumier, Raphaelle, Franchet, Camille, Ligat, Laetitia, Lopez, Fréderic, Record, Michel, Poirot, Marc, Silvente-Poirot, Sandrine
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5676900/
https://ncbi.nlm.nih.gov/pubmed/29078321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1707965114
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