Sirt1 Protects Endothelial Cells against LPS-Induced Barrier Dysfunction

Sepsis is a threatening health problem and characterized by microvascular dysfunction. In this study, we verified that LPS caused the downregulation of Sirt1 and the hyperpermeability of endothelial cells. Inhibition of Sirt1 with ex527 or Sirt1 siRNA displayed a higher permeability, while activatio...

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Dettagli Bibliografici
Pubblicato in:Oxid Med Cell Longev
Autori principali: Zhang, Weijin, Zhang, Yaoyuan, Guo, Xiaohua, Zeng, Zhenhua, Wu, Jie, Liu, Yanan, He, Jing, Wang, Ruiting, Huang, Qiaobing, Chen, Zhongqing
Natura: Artigo
Lingua:Inglês
Pubblicazione: Hindawi 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5676476/
https://ncbi.nlm.nih.gov/pubmed/29209448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/4082102
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