Sirt1 Protects Endothelial Cells against LPS-Induced Barrier Dysfunction

Sepsis is a threatening health problem and characterized by microvascular dysfunction. In this study, we verified that LPS caused the downregulation of Sirt1 and the hyperpermeability of endothelial cells. Inhibition of Sirt1 with ex527 or Sirt1 siRNA displayed a higher permeability, while activatio...

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Detalhes bibliográficos
Publicado no:Oxid Med Cell Longev
Main Authors: Zhang, Weijin, Zhang, Yaoyuan, Guo, Xiaohua, Zeng, Zhenhua, Wu, Jie, Liu, Yanan, He, Jing, Wang, Ruiting, Huang, Qiaobing, Chen, Zhongqing
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5676476/
https://ncbi.nlm.nih.gov/pubmed/29209448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/4082102
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