Sirt1 Protects Endothelial Cells against LPS-Induced Barrier Dysfunction

Sepsis is a threatening health problem and characterized by microvascular dysfunction. In this study, we verified that LPS caused the downregulation of Sirt1 and the hyperpermeability of endothelial cells. Inhibition of Sirt1 with ex527 or Sirt1 siRNA displayed a higher permeability, while activatio...

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Veröffentlicht in:Oxid Med Cell Longev
Hauptverfasser: Zhang, Weijin, Zhang, Yaoyuan, Guo, Xiaohua, Zeng, Zhenhua, Wu, Jie, Liu, Yanan, He, Jing, Wang, Ruiting, Huang, Qiaobing, Chen, Zhongqing
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5676476/
https://ncbi.nlm.nih.gov/pubmed/29209448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/4082102
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