An Albumin-Oligonucleotide Assembly for Potential Combinatorial Drug Delivery and Half-Life Extension Applications

The long blood circulatory property of human serum albumin, due to engagement with the cellular recycling neonatal Fc receptor (FcRn), is an attractive drug half-life extension enabling technology. This work describes a novel site-specific albumin double-stranded (ds) DNA assembly approach, in which...

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Pubblicato in:Mol Ther Nucleic Acids
Autori principali: Kuhlmann, Matthias, Hamming, Jonas B.R., Voldum, Anders, Tsakiridou, Georgia, Larsen, Maja T., Schmøkel, Julie S., Sohn, Emil, Bienk, Konrad, Schaffert, David, Sørensen, Esben S., Wengel, Jesper, Dupont, Daniel M., Howard, Kenneth A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5676087/
https://ncbi.nlm.nih.gov/pubmed/29246307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2017.10.004
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