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Loss of SIRT2 leads to axonal degeneration and locomotor disability associated with redox and energy imbalance

Sirtuin 2 (SIRT2) is a member of a family of NAD (+)‐dependent histone deacetylases (HDAC) that play diverse roles in cellular metabolism and especially for aging process. SIRT2 is located in the nucleus, cytoplasm, and mitochondria, is highly expressed in the central nervous system (CNS), and has b...

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Dades bibliogràfiques
Publicat a:Aging Cell
Autors principals: Fourcade, Stéphane, Morató, Laia, Parameswaran, Janani, Ruiz, Montserrat, Ruiz‐Cortés, Tatiana, Jové, Mariona, Naudí, Alba, Martínez‐Redondo, Paloma, Dierssen, Mara, Ferrer, Isidre, Villarroya, Francesc, Pamplona, Reinald, Vaquero, Alejandro, Portero‐Otín, Manel, Pujol, Aurora
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5676070/
https://ncbi.nlm.nih.gov/pubmed/28984064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12682
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