Loss of SIRT2 leads to axonal degeneration and locomotor disability associated with redox and energy imbalance

Sirtuin 2 (SIRT2) is a member of a family of NAD (+)‐dependent histone deacetylases (HDAC) that play diverse roles in cellular metabolism and especially for aging process. SIRT2 is located in the nucleus, cytoplasm, and mitochondria, is highly expressed in the central nervous system (CNS), and has b...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Fourcade, Stéphane, Morató, Laia, Parameswaran, Janani, Ruiz, Montserrat, Ruiz‐Cortés, Tatiana, Jové, Mariona, Naudí, Alba, Martínez‐Redondo, Paloma, Dierssen, Mara, Ferrer, Isidre, Villarroya, Francesc, Pamplona, Reinald, Vaquero, Alejandro, Portero‐Otín, Manel, Pujol, Aurora
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5676070/
https://ncbi.nlm.nih.gov/pubmed/28984064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12682
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