載入...
Site-Specific Modification Using the 2′-Methoxyethyl Group Improves the Specificity and Activity of siRNAs
Rapid progress has been made toward small interfering RNA (siRNA)-based therapy for human disorders, but rationally optimizing siRNAs for high specificity and potent silencing remains a challenge. In this study, we explored the effect of chemical modification at the cleavage site of siRNAs. We found...
Na minha lista:
| 發表在: | Mol Ther Nucleic Acids |
|---|---|
| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society of Gene & Cell Therapy
2017
|
| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5675723/ https://ncbi.nlm.nih.gov/pubmed/29246303 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2017.10.003 |
| 標簽: |
添加標簽
沒有標簽, 成為第一個標記此記錄!
|