IRAK2 directs stimulus-dependent nuclear export of inflammatory mRNAs

Expression of inflammatory genes is determined in part by post-transcriptional regulation of mRNA metabolism but how stimulus- and transcript-dependent nuclear export influence is poorly understood. Here, we report a novel pathway in which LPS/TLR4 engagement promotes nuclear localization of IRAK2 t...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Zhou, Hao, Bulek, Katarzyna, Li, Xiao, Herjan, Tomasz, Yu, Minjia, Qian, Wen, Wang, Han, Zhou, Gao, Chen, Xing, Yang, Hui, Hong, Lingzi, Zhao, Junjie, Qin, Luke, Fukuda, Koichi, Flotho, Annette, Gao, Ji, Dongre, Ashok, Carman, Julie A, Kang, Zizhen, Su, Bing, Kern, Timothy S, Smith, Jonathan D, Hamilton, Thomas A, Melchior, Frauke, Fox, Paul L, Li, Xiaoxia
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5675595/
https://ncbi.nlm.nih.gov/pubmed/28990926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.29630
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