IL-17 receptor-associated adaptor Act1 directly stabilizes mRNAs to mediate IL-17 inflammatory signaling

Mechanisms that degrade inflammatory mRNAs are well-known, however stabilizing mechanisms are poorly understood. Here we show that Act1, an interleukin-17 (IL-17) receptor complex adaptor, binds and stabilizes mRNAs encoding key inflammatory proteins. The Act1 SEFIR domain binds a stem-loop structur...

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Detalhes bibliográficos
Publicado no:Nat Immunol
Main Authors: Herjan, Tomasz, Hong, Lingzi, Bubenik, Jodi, Bulek, Katarzyna, Qian, Wen, Liu, Caini, Li, Xiao, Chen, Xing, Yang, Hui, Ouyang, Suidong, Zhou, Hao, Zhao, Junjie, Komireddy, Vasu, Cockman, Eric, Aronica, Mark, Asosingh, Kewal, Licatalosi, Donny D., Qin, Jun, Fox, Paul L., Hamilton, Thomas A., Driscoll, Donna, Li, Xiaoxia
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6082628/
https://ncbi.nlm.nih.gov/pubmed/29563620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-018-0071-9
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