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The critical role of epithelial-derived Act1 in IL-17- and IL-25-mediated pulmonary inflammation
IL-25 initiates, promotes, and augments Th2 immune responses. We here report that Act1, a key component in IL-17-mediated signaling, is an essential signaling molecule for IL-25 signaling. While Act1-deficient mice showed reduced expression of KC (CXCL1) and neutrophil recruitment to the airway comp...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3015148/ https://ncbi.nlm.nih.gov/pubmed/19155512 |
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