A CC′ Loop Decoy Peptide Blocks the Interaction Between Act1 and IL-17RA to Attenuate IL-17- and IL-25-Induced Inflammation

Interleukin-17 (IL-17) and IL-25 signaling induce the expression of genes that encode inflammatory factors and they are implicated in the pathology of various inflammatory diseases. Nuclear factor κB (NF-κB) activator 1 (Act1) is an adaptor protein and E3 ubiquitin ligase that is critical for IL-17...

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Autores principales: Liu, Caini, Swaidani, Shadi, Qian, Wen, Kang, Zizhen, Sun, Paige, Han, Yue, Wang, Chenhui, Gulen, Muhammet Fatih, Yin, Weiguo, Zhang, Chunjiang, Fox, Paul L, Aronica, Mark, Hamilton, Thomas A, Misra, Saurav, Deng, Junpeng, Li, Xiaoxia
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3282585/
https://ncbi.nlm.nih.gov/pubmed/22045852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2001843
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