Inhibition of IRAK4 kinase activity improves ethanol-induced liver injury in mice

BACKGROUNDS & AIMS: Alcohol-related liver disease (ALD) is a major cause of chronic liver disease worldwide with limited therapeutic options. Interleukin-1 Receptor Associated Kinase 4 (IRAK4), the master kinase of TLRs/IL-1R-mediated signaling activation, is considered a novel therapeutic targe...

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Publicado no:J Hepatol
Main Authors: Wang, Han, Zhou, Hao, Zhang, Quanri, Poulsen, Kyle L., Taylor, Vanessa, McMullen, Megan R., Czarnecki, Doug, Dasarathy, Dhweeja, Yu, Minjia, Liao, Yun, Allende, Daniela S., Chen, Xing, Hong, Lingzi, Zhao, Junjie, Yang, Jinbo, Nagy, Laura E., Li, Xiaoxia
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8007112/
https://ncbi.nlm.nih.gov/pubmed/32682051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2020.07.016
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