The non-transcriptional activity of IRF3 modulates hepatic immune cell populations in acute on chronic ethanol administration in mice

BACKGROUND & AIMS: Interferon regulatory factor 3 (IRF3) is a transcription factor mediating anti-viral responses, yet recent evidence indicates that IRF3 also has critical non-transcriptional functions, including activating RIG-I-like receptors-induced IRF-3-mediated pathway of apoptosis (RIPA)...

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Detalhes bibliográficos
Publicado no:J Hepatol
Main Authors: Sanz-Garcia, Carlos, Poulsen, Kyle L., Bellos, Damien, Wang, Han, McMullen, Megan R., Li, Xiaoxia, Chattopadhyay, Saurabh, Sen, Ganes, Nagy, Laura E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6462245/
https://ncbi.nlm.nih.gov/pubmed/30710579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2019.01.021
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