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Meet the terminator: the phosphatase PP2A puts brakes on IRF-3 activation
Cellular interferon response to microbial infection is transient; In a recently paper in Immunity, Long et al identifies PP2A phosphatase as a deactivator of phospho-IRF-3, the key transcription factor for interferon synthesis, thus providing one basis for the observed transiency.
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4053166/ https://ncbi.nlm.nih.gov/pubmed/24766884 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.04.008 |
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