IL-1 induces mitochondrial translocation of IRAK2 to suppress oxidative metabolism in adipocytes

Chronic inflammation is a common feature of obesity with elevated cytokines such as Interleukin-1 (IL-1) in circulation and tissues. Here, we report an unconventional IL-1R-MyD88-IRAK2-PHB/OPA1 signaling axis that reprograms mitochondrial metabolism in adipocytes to exacerbate obesity. IL-1 induced...

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Publicado no:Nat Immunol
Main Authors: Zhou, Hao, Wang, Han, Yu, Minjia, Schugar, Rebecca C., Qian, Wen, Tang, Fangqiang, Liu, Weiwei, Yang, Hui, McDowell, Ruth E., Zhao, Junjie, Gao, Ji, Dongre, Ashok, Carman, Julie A., Yin, Mei, Drazba, Judith A., Dent, Robert, Hine, Christopher, Chen, Yeong-Renn, Smith, Jonathan D., Fox, Paul L., Brown, J. Mark, Li, Xiaoxia
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7566776/
https://ncbi.nlm.nih.gov/pubmed/32778760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-020-0750-1
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