A carregar...

Evaluation of DILI Predictive Hypotheses in Early Drug Development

Drug-induced liver injury (DILI) is a leading cause of drug failure in clinical trials and a major reason for drug withdrawals. DILI has been shown to be dependent on both daily dose and extent of hepatic metabolism. Yet, early in drug development daily dose is unknown. Here, we perform a comprehens...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Chem Res Toxicol
Main Authors: Chan, Rosa, Benet, Leslie Z.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5674994/
https://ncbi.nlm.nih.gov/pubmed/28257576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.7b00025
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!