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Evaluation of DILI Predictive Hypotheses in Early Drug Development
Drug-induced liver injury (DILI) is a leading cause of drug failure in clinical trials and a major reason for drug withdrawals. DILI has been shown to be dependent on both daily dose and extent of hepatic metabolism. Yet, early in drug development daily dose is unknown. Here, we perform a comprehens...
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| Yayımlandı: | Chem Res Toxicol |
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| Asıl Yazarlar: | , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2017
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5674994/ https://ncbi.nlm.nih.gov/pubmed/28257576 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.7b00025 |
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