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Measures of BSEP Inhibition In Vitro Are Not Useful Predictors of DILI

Inhibition of the bile salt export pump (BSEP) by a drug has been implicated as a risk factor for a drug’s potential to cause drug-induced liver injury (DILI) and is thought to be an important mechanism leading to DILI. For a wide variety of drugs a correlation has been observed between the potency...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Toxicol Sci
Main Authors: Chan, Rosa, Benet, Leslie Z
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5888978/
https://ncbi.nlm.nih.gov/pubmed/29272540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfx284
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