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Measures of BSEP Inhibition In Vitro Are Not Useful Predictors of DILI
Inhibition of the bile salt export pump (BSEP) by a drug has been implicated as a risk factor for a drug’s potential to cause drug-induced liver injury (DILI) and is thought to be an important mechanism leading to DILI. For a wide variety of drugs a correlation has been observed between the potency...
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| Veröffentlicht in: | Toxicol Sci |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5888978/ https://ncbi.nlm.nih.gov/pubmed/29272540 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfx284 |
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