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Reliability of in vitro and in vivo methods for predicting P-glycoprotein effect on antidepressants delivery to the brain

As P-glycoprotein (P-gp) transport on antidepressant delivery has been extensively evaluated using in vitro cellular and in vivo rodent models, an increasing number of publications addressed the effect of P-gp in limiting brain penetration of antidepressants and causing treatment-resistant depressio...

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Библиографические подробности
Опубликовано в: :Clin Pharmacokinet
Главные авторы: Zheng, Yi, Chen, Xijing, Benet, Leslie Z.
Формат: Artigo
Язык:Inglês
Опубликовано: 2016
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5674979/
https://ncbi.nlm.nih.gov/pubmed/26293617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-015-0310-2
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