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pH dependent but not P-gp dependent bidirectional transport study of S-propranolol: the importance of passive diffusion
PURPOSE: Recent controversial publications, citing studies purporting to show that P-gp mediates the transport of propranolol, proposed that passive biological membrane transport is negligible. Based on the BDDCS, the extensively metabolized-highly permeable-highly soluble BDDCS class 1 drug, propra...
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| Publicado no: | Pharm Res |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4891189/ https://ncbi.nlm.nih.gov/pubmed/25690341 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-015-1640-3 |
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