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Reliability of in vitro and in vivo methods for predicting P-glycoprotein effect on antidepressants delivery to the brain
As P-glycoprotein (P-gp) transport on antidepressant delivery has been extensively evaluated using in vitro cellular and in vivo rodent models, an increasing number of publications addressed the effect of P-gp in limiting brain penetration of antidepressants and causing treatment-resistant depressio...
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| Published in: | Clin Pharmacokinet |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5674979/ https://ncbi.nlm.nih.gov/pubmed/26293617 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-015-0310-2 |
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