A neuroprotective agent that inactivates prodegenerative TrkA and preserves mitochondria

Axon degeneration is an early event and pathological in neurodegenerative conditions and nerve injuries. To discover agents that suppress neuronal death and axonal degeneration, we performed drug screens on primary rodent neurons and identified the pan-kinase inhibitor foretinib, which potently resc...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Cell Biol
Main Authors: Feinberg, Konstantin, Kolaj, Adelaida, Wu, Chen, Grinshtein, Natalie, Krieger, Jonathan R., Moran, Michael F., Rubin, Lee L., Miller, Freda D., Kaplan, David R.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2017
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5674898/
https://ncbi.nlm.nih.gov/pubmed/28877995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201705085
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