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A neuroprotective agent that inactivates prodegenerative TrkA and preserves mitochondria

Axon degeneration is an early event and pathological in neurodegenerative conditions and nerve injuries. To discover agents that suppress neuronal death and axonal degeneration, we performed drug screens on primary rodent neurons and identified the pan-kinase inhibitor foretinib, which potently resc...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:J Cell Biol
मुख्य लेखकों: Feinberg, Konstantin, Kolaj, Adelaida, Wu, Chen, Grinshtein, Natalie, Krieger, Jonathan R., Moran, Michael F., Rubin, Lee L., Miller, Freda D., Kaplan, David R.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: The Rockefeller University Press 2017
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5674898/
https://ncbi.nlm.nih.gov/pubmed/28877995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201705085
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