A neuroprotective agent that inactivates prodegenerative TrkA and preserves mitochondria

Axon degeneration is an early event and pathological in neurodegenerative conditions and nerve injuries. To discover agents that suppress neuronal death and axonal degeneration, we performed drug screens on primary rodent neurons and identified the pan-kinase inhibitor foretinib, which potently resc...

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Publicado en:J Cell Biol
Autores principales: Feinberg, Konstantin, Kolaj, Adelaida, Wu, Chen, Grinshtein, Natalie, Krieger, Jonathan R., Moran, Michael F., Rubin, Lee L., Miller, Freda D., Kaplan, David R.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2017
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5674898/
https://ncbi.nlm.nih.gov/pubmed/28877995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201705085
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