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A neuroprotective agent that inactivates prodegenerative TrkA and preserves mitochondria
Axon degeneration is an early event and pathological in neurodegenerative conditions and nerve injuries. To discover agents that suppress neuronal death and axonal degeneration, we performed drug screens on primary rodent neurons and identified the pan-kinase inhibitor foretinib, which potently resc...
Gespeichert in:
Veröffentlicht in: | J Cell Biol |
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Hauptverfasser: | , , , , , , , , |
Format: | Artigo |
Sprache: | Inglês |
Veröffentlicht: |
The Rockefeller University Press
2017
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Schlagworte: | |
Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5674898/ https://ncbi.nlm.nih.gov/pubmed/28877995 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201705085 |
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